“Wear a mask. It’s a sign of respect,” Gaga said during one of her several appearances onstage as she accepted awards like artist and song of the year.

With an electronic mask, Gaga performed a medley of her songs, including “Stupid Love,” “Chromatica II” and “911.” She and Grande were joined by a number of background dancers all wearing masks.

The Weeknd, the first performer of the night, paid tribute to Blake and Taylor — two Black people who were shot by police officers — after winning video of the year and best R&B for “Blinding Lights.”

“It’s really hard for me to celebrate right now and enjoy this moment, so I’m just going to say: justice for Jacob Blake and justice for Breonna Taylor,” he said.

The VMAs kicked off with another touching moment, as host Keke Palmer told viewers the show was dedicated to Chadwick Boseman, who died Friday after privately battling colon cancer for four years at age 43.

“We dedicate tonight’s show to a man whose spirit touched so many. He’s a true hero, not just on-screen,” Palmer said. “His impact lives forever.”

The Black Eyed Peas, who closed the two-hour-plus show with Nicky Jam and Tyga, ended their set by saying, “Black Lives Matter.” And R&B star H.E.R. won the video for good award for her protest anthem about police brutality and systemic racism, “I Can’t Breathe.”

“I’m super proud of everybody speaking out on social injustice,” H.E.R. said.

But most of the show was dedicated to fun performances — some pre-taped, some filmed in various locations in New York City.

Pop all-stars BTS, who won four awards including best pop and best group, were top-notch during a pre-taped performance, which featured their signature, skilled choreography. The seven band members danced and sang in sharp suits, at some points with the backdrop of Times Square behind them.

The VMAs, originally supposed to be held at the Barclays Center in Brooklyn, featured Colombian singer and best Latin winner Maluma singing from Brooklyn, while The Weeknd performed from Manhattan.

DaBaby, backed by the dance crew Jabbawockeez, ran through several of his hits, including “Rock Star.” During the latter track, he rapped while jumping on top of a police car, with a burning city as his backdrop. Doja Cat, who was named Push best new artist, gave a futuristic performances of her hits “Say So” and “Like That.”

Other performers included Latin boy band CNCO and Miley Cyrus, who ended her performance of “Midnight Sky” by sitting a top of a large disco ball, replicating like her viral “Wrecking Ball” clip from 2013.

As for top honors, Grande tied BTS with four wins. Her No. 1 duet with Justin Bieber, “Stuck with U,” won best music video from home — one of two new awards MTV established as artists have made shifts because of the pandemic. CNCO won best quarantine performance for “MTV Unplugged at Home.”

Megan Thee Stallion won best hip-hop for “Savage” and Taylor Swift won best direction for “The Man.”

“This is the very first video that I’ve ever directed on my own. And I just I’m so grateful for this,” Swift said. “I wanted to take an opportunity to say thank to the team who believed in me as a first-time director and made this video with me.”